Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer

References

ref title DOI material type comment
3405 174 Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer https://doi.org/10.1016/j.biomaterials.2020.119848 Composite IrRu-GOx@PEG NPs

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7465 174 IrRu-GOx@PEG NPs 43 nm TEM Therefore, we synthesized IrRu NPs with different ratio of Ir and Ru elements to obtain better enzyme-like catalytic activity. the TEM image showed Ir2Ru1 NPs, Ir4Ru1 NPs, and Ir8Ru1 NPs are uniformly dispersed black particles with an average particle size of ~2 nm (Fig. 1A and B) and ~3 nm (Figs. S1A and B), ~4 nm.As shown in TEM images, the IrRuGOx@PEG NPs obtained by PEG-coated IrRu NPs were spherical and the average particle size was ~43 nm

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6064 174 IrRu-GOx@PEG NPs POD H2O2 6.0 20.01 mM 2.12 -8 M/s 174
6063 174 IrRu-GOx@PEG NPs POD TMB 6.0 0.351 mM 174

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5083 174 IrRu-GOx@PEG NPs Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer