Graphdiyne-templated palladium-nanoparticle assembly as a robust oxygen generator to attenuate tumor hypoxia

References

ref title DOI material type comment
3518 321 Graphdiyne-templated palladium-nanoparticle assembly as a robust oxygen generator to attenuate tumor hypoxia https://doi.org/10.1016/j.nantod.2020.100907 Composite Here, we described a strategy to prepare a stable nanocatalyst that two-dimensional (2D) graphdiyne (GDY) serves as a template to immobilize catalytic palladium nanoparticles (PdNPs) on the GDY surface. In the presence of H2O2, the PdNPs/GDY composite functions as an oxygen generator to decompose H2O2 to produce molecular oxygen, which efficiently attenuates tumor hypoxia and delays tumor growth

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7563 321 PdNPs/GDY 3.1 nm TEM In contrast, many Pd nanoparticles, with an average size of 3.1 nm, were observed and uniformly distributed on the GDY sheet after reduction with NaBH4 (Fig. 1c and d, Fig. S2), demonstrating the successful preparation of the PdNPs/GDY composite.

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6203 321 PdNPs/GDY CAT H2O2 59 mM 342.9 μM/s 321 321

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5211 321 PdNPs/GDY Our findings demonstrate that the rational design of a nano