Zinc oxide particles catalytically generate nitric oxide from endogenous and exogenous prodrugs

References

ref title DOI material type comment
3564 375 Zinc oxide particles catalytically generate nitric oxide from endogenous and exogenous prodrugs https://doi.org/10.1002/smll.201906744 Metal oxide Zinc oxide (ZnO) particles

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7611 375 ZnO 10.1 1.8 μm SEM The average size of the bowtie was 10.1 ± 1.8 μm (length) and 2.6 ± 0.9 μm (width, defined as the distance of the two outmost branches at the edge) (Fig. 1ai and aii).

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5280 375 ZnO NO-releasing biomaterials and devices NO E-chem 1 × 10−9 M
5279 375 ZnO NO-releasing biomaterials and devices NO E-chem 1 × 10−9 M In detail, the probe was suspended in a glass vial filled with 10 mL 0.1 M H2SO4/0.1 M KI solution. Incremental volumes of 25 × 10−6 m KNO2 solution were added to the glass vial after a stable current baseline was observed. NO concentration was determined based on the amount of KNO2 added as the conversion of KNO2 to NO was stoichiometrically 1:1. To assess the capability of ZnO particles to catalyze GSNO to generate NO, the NO probe was placed in a glass vial containing 3.95 mL ZnO particles (0.1–0.4 g L−1) in PBS. Fifty microliters of GSNO solutions (5× 10−6–100 × 10−6 m) was added to the glass vial when a stable baseline was reached. Changes in current response were recorded over time using LabScribe2 software. All NO measurements were carried out in dark at 37 °C on a hot plate with constant stirring.