Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

References

ref title DOI material type comment
3269 38 Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy https://doi.org/10.1126/sciadv.abb2695 Composite an integrated SOD/CAT mimetic cascade nanozyme (designated as Pt@PCN222-Mn) by introducing an SOD-like moiety of Mn(III) porphyrin and a CAT-like Pt NP within a nanoscale Zr-based MOF, PCN222

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7358 38 Pt@PCN222-Mn 200 nm TEM

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
5927 38 Pt@PCN223-Mn CAT H2O2 38 38
5926 38 Pt@PCN222-Mn SOD •O2− 38 38

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
4971 38 Pt@PCN222-Mn ROS scavenge •O2−