Targeted self-activating Au-Fe3O4 composite nanocatalyst for enhanced precise hepatocellular carcinoma therapy via dual nanozyme-catalyzed cascade reactions

References

ref title DOI material type comment
3992 806 Targeted self-activating Au-Fe3O4 composite nanocatalyst for enhanced precise hepatocellular carcinoma therapy via dual nanozyme-catalyzed cascade reactions https://doi.org/10.1016/j.apmt.2020.100827 Composite Briefly, the composite nanozyme CD44MMSN/AuNPs were assembled with two self-activable nanocatalysts including the inner core peroxidase-mimic Fe3O4 magnetic nanoparticles (MNPs), and the outer glucose oxidase-mimic AuNPs situated within large aperture mesoporous silicon (MMSN/AuNPs), and then functionalized with cell ligand hyaluronic acid (HA)

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8013 806 CD44MMSN/AuNPs 417.39

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6711 806 CD44MMSN/AuNPs POD TMB 15.37 mM 9.06 -8 M/s 806
6710 806 CD44MMSN/AuNPs POD H2O2 6.35 mM 3.85 -8 M/s 806

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5731 806 CD44MMSN/AuNPs enhanced precise hepatocellular carcinoma therapy