Tumor Microenvironment-Activatable Cyclic Cascade Reaction to Reinforce Multimodal Combination Therapy by Destroying the Extracellular Matrix

References

ref title DOI material type comment
4208 1021 Tumor Microenvironment-Activatable Cyclic Cascade Reaction to Reinforce Multimodal Combination Therapy by Destroying the Extracellular Matrix https://doi.org/10.1021/acsami.1c02011 Composite an intelligent BPNs-Arg-GOx@MnO2 (BAGM) nanozyme is innovatively designed as a multimodal synergistic therapeutic paradigm that possesses both nitric oxide (NO) self-supplying and ECM degradation properties to reinforce the therapy effect by a tumor microenvironment (TME)- activatable cyclic cascade catalytic

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6954 1021 BPNs-Arg-GOx@MnO2 (BAGM) 1021

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5930 1021 BPNs-Arg-GOx@MnO2 (BAGM) In summary, we have successfully structured a TME-activatable BAGM nanozyme for an MR/US imaging-guided multimodal synergistic therapy nanoplatform with PTT/starvation therapy/NO gas therapy