Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengers

References

ref title DOI material type comment
4249 1062 Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengers https://doi.org/10.1002/adma.202006570 Composite Fenozymes

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8125 1062 MnO2 Fenozymes TEM Transmission electron microscopy (TEM) revealed the uniform diameter of the hollow structure of FTn was ≈12 nm after protein negative staining (Figure 1b). The diameter of FTn inner cavity is 8 nm, and the incorporated MnO2 nanozymes within the FTn core (MnO2 Fenozymes) were observed by TEM. The MnO2 Fenozymes showed monodispersed spherical morphology (Figure 1c) with mean diameters of ≈6.5 nm, which did not change after TPP conjugation (Figure 1d).

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
7016 1062 MnO2 Fenozyme POD TMB 6.36 mM 2.74 nM/s 15.42 -3 1/s 1062 M-1 s-1 1062
7015 1062 MnO2 Fenozyme CAT H2O2 11.43 mM 489.60 nM/s 2.2 1 1/s 1062 3 M-1 s-1 1062
7014 1062 Fe3 O4 Fenozyme CAT H2O2 13.21 mM 548.70 nM/s 2.47 1 1/s 1062 3 M-1 s-1 1062
7013 1062 Fe3 O4 Fenozyme POD TMB 7.08 mM 28.08 nM/s 157.95 -3 1/s 1062 M-1 s-1 1062

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5975 1062 Fenozymes Superoxide Scavengers