Intracellular Activation of Anticancer Therapeutics Using Polymeric Bioorthogonal Nanocatalysts

References

ref title DOI material type comment
4253 1066 Intracellular Activation of Anticancer Therapeutics Using Polymeric Bioorthogonal Nanocatalysts https://doi.org/10.1002/adhm.202001627 Composite a ruthenium-based “polyzyme” employing a poly(oxanorbornene imide) scaffold

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8132 1066 polyzymes 80 nm DLS Transmission electron microscopy (TEM, Figure S7, Supporting Information) indicated a diameter of ≈30 nm (dry). Dynamic light scattering (DLS, Figure S7, Supporting Information) showed that the size of the self-assemblies was ≈80 nm in solution, indicating some degree of swelling of self-assembled NP in aqueous media.
8131 1066 polyzymes 30 nm TEM Transmission electron microscopy (TEM, Figure S7, Supporting Information) indicated a diameter of ≈30 nm (dry). Dynamic light scattering (DLS, Figure S7, Supporting Information) showed that the size of the self-assemblies was ≈80 nm in solution, indicating some degree of swelling of self-assembled NP in aqueous media.

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5979 1066 polyzymes Intracellular Activation of Anticancer Therapeutics