Biphasic Synthesis of Biodegradable Urchin-Like Mesoporous Organosilica Nanoparticles for Enhanced Cellular Internalization and Precision Cascaded Therapy

References

ref title DOI material type comment
4386 1201 Biphasic Synthesis of Biodegradable Urchin-Like Mesoporous Organosilica Nanoparticles for Enhanced Cellular Internalization and Precision Cascaded Therapy https://doi.org/10.1039/d1bm00015b Composite TME-responsive ultrasmall gold-capped UMONs (UMONs–Au) through ion–ligand interactions between amino group-functionalized UMONs (UMONs–NH2) and l-cysteine-derived ultrasmall gold nanoparticles (AuNPs–Cys) with bridged ferrous ions

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8235 1201 UMONs-LA-Au 2.4 nm TEM After ultrasmall gold capping, the average pore size of UMONs–Au was decreased to approximately 2.4 nm, accompanied by the decrease of BET surface area from 873.2 m2 g−1 to 489.5 m2 g−1 489.5

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
7148 1201 UMONs-LA-Au LA–H2O2 37 1201

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
6088 1201 UMONs-LA-Au promoted the oxidation of LA for an improved NO yield, which led to significant nanocatalysis-enhanced NO gas therapy for tumor eradication