Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

References

ref title DOI material type comment
3783 596 Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy https://doi.org/10.1039/D0TB00357C Composite an efficient ROS generator (GOx@Pd@ZIF-8). Glucose oxidase (GOx) and palladium (Pd) cube nanozymes were incorporated in zeolitic imidazolate framework-8 (ZIF-8) by biomimetic mineralization.

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7822 596 GOx@Pd@ZIF-8 SEM The average particle size was ca. 130 nm as obtained from SEM measurements, while the value was measured to be 480 nm using the DLS method (Fig. S2, ESI†).

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6479 596 GOx@Pd@ZIF-8 OXD 596 596

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5531 596 GOx@Pd@ZIF-8 a synergistic cancer therapeutic that blocks glucose metabolism and produces ROS