Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors

References

ref title DOI material type comment
3805 619 Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors https://doi.org/10.1016/j.biomaterials.2020.120537 Composite integrating DOX with the Fe(VI)-nanoplatform, followed by incorporation of n-heneicosane (HE) and polyethylene glycol (PEG) chains (designated as DOX-Fe(VI)@HMS-HE-PEG, abbreviated as DFHHP)

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7842 619 DFHHP The constructed HMS was ca. 100 nm in diameter (Fig. 1A and B). The average hydrodynamic particle diameters of HMS and DFHHP were ca. 150 nm with a narrow size distribution (Fig. 1E), indicating good dispersion of these nanomaterials in aqueous media.

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6505 619 DFHHP CAT H2O2 619 619

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5556 619 DFHHP overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors