Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation

References

ref title DOI material type comment
3896 710 Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation https://doi.org/10.1021/acsabm.0c00056 Composite Herein, we fabricated a nanozyme platform (Fe@Fe3O4@Cu2-xS, named as MNPs) possessing peroxidase enzyme-like activity, and then introduced β-Lapachone (La) to assemble an effective nanozyme (LaMNPs) to boost the production of reactive oxygen species and upregulate the level of H2O2 by the released La in an acidic tumor microenvironment

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7922 710 LaMNPs-PEG 71 nm DLS The HD and potential of LaMNPs-PEG were about ~71 nm and ~-27.3 mV by dynamic light scattering (DLS)

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6592 710 MNPs-PEG POD TMB 0.18 mM 54 -8 M/s 710
6591 710 MNPs-PEG POD H2O2 0.17 mM 42 -8 M/s 710

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5635 710 LaMNPs inhibition of the tumor growth