Nanozyme Database

	ref	title	DOI	material type	comment
4178	992	Fe3O4@ Pt nanozymes combining with CXCR4 antagonists to synergistically treat acute myeloid leukemia	https://doi.org/10.1016/j.nantod.2021.101106	Composite	To overcome these problems, a multifunctional nanoplatform of Fe3O4@Pt composite nanozyme conjugating CXCR4 antagonist was designed, aiming to synergistically treat AML for the first time, in which, the CXCR4 antagonist was used to specifically target AML cells as well as to significantly interfere CXCR4/CXCL12 axis. In the mildly acidic lysosome microenvironment, highly toxic reactive oxygen species (ROS) was generated through the sequential catalytic reactions of Fe3O4@Pt to trigger AML cells apoptosis, leaving the normal cells unharmed.

	ref	material	size	size err	size unit	size type	size comment	BET	b _nanozyme	b 10ⁿ	b unit	specific act	sa 10ⁿ	sa unit	comment

	ref	material	enzyme type	substrate	pH	T	k_m	k_m err	k_m 10ⁿ	k_m unit	v_max	v_max err	v_max 10ⁿ	v_max unit	k_cat	k_cat err	k_cat 10ⁿ	k_cat unit	k_cat/k_m	k_cat/k_m 10ⁿ	k_cat/k_m unit	comment
6906	992	Fe3O4@PEG	POD	H2O2	2-11	20-80	22.59			mM	0.028		-6	M/s					992
6901	992	Fe3O4@PEG	POD	H2O2			13.768			mM	29.06		-8	M/s					992

	ref	material	application	target	method	linear range	linear ran unit	LOD	lod unit	recovery	comment
5899	992	Fe3O4@Pt@E5	AML treatment