| 3266 |
35 |
Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases |
https://doi.org/10.1038/s41467-020-16544-7 |
Metal oxide |
ultrasmall Cu5.4O nanoparticles (Cu5.4O USNPs) |
| 3269 |
38 |
Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy |
https://doi.org/10.1126/sciadv.abb2695 |
Composite |
an integrated SOD/CAT mimetic cascade nanozyme (designated as Pt@PCN222-Mn) by introducing an SOD-like moiety of Mn(III) porphyrin and a CAT-like Pt NP within a nanoscale Zr-based MOF, PCN222 |
| 3270 |
39 |
A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and … |
https://doi.org/10.1002/adma.202001862 |
Multi-metal |
a new bimetallic and biphasic Rh-based core–shell nanosystem (Au@Rh-ICG-CM) |
| 3280 |
49 |
Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics |
https://doi.org/10.1016/j.biomaterials.2019.119635 |
Composite |
hypoxia-tropic nanozyme as oxygen generator (OGzyme) by the biomimetic synthesis of MnO2 nanoparticles inside the hollow cavity of FTn |
| 3283 |
52 |
Nanoenzyme-Reinforced Injectable Hydrogel for Healing Diabetic Wounds Infected with Multidrug Resistant Bacteria |
https://doi.org/10.1021/acs.nanolett.0c01371 |
Composite |
EPL-coated MnO2 nanosheets (EM) and insulin-encapsulated aldehyde Pluronic F127 (FCHO) micelles |
| 3369 |
138 |
Ru@ CeO2 yolk shell nanozymes: Oxygen supply in situ enhanced dual chemotherapy combined with photothermal therapy for orthotopic/subcutaneous colorectal cancer |
https://doi.org/10.1016/j.biomaterials.2020.119923 |
Composite |
hollow Ru@CeO2 yolk shell nanozymes |
| 3371 |
140 |
Solving the H2O2 by-product problem using a catalase-mimicking nanozyme cascade to enhance glycolic acid oxidase |
https://doi.org/10.1016/j.cej.2020.124249 |
Others |
Fe3+ and adenosine monophosphate coordination nanoparticles |
| 3386 |
155 |
Ultrasmall theranostic nanozymes to modulate tumor hypoxia for augmenting photodynamic therapy and radiotherapy |
https://doi.org/10.1039/C9BM01742A |
Metal |
indocyanine green (ICG)-loaded ultrasmall gold nanoclusters |
| 3388 |
157 |
GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy |
https://doi.org/10.1002/adma.202002439. |
Composite |
PEG/Ce-Bi@DMSN |
| 3461 |
230 |
Hollow magnetic nanosystem-boosting synergistic effect between magnetic hyperthermia and sonodynamic therapy via modulating reactive oxygen species and heat shock proteins |
https://doi.org/10.1016/j.cej.2020.124521 |
Composite |
HP-HIONs@PDA-PEG containing hollow magnetic nanoparticles (HIONs), hematoporphyrin (HP), polydopamine (PDA), and polyethylene glycol (PEG) |
| 3478 |
271 |
Facile synthesis of magnetic hierarchical flower-like Co3O4 spheres: Mechanism, excellent tetra-enzyme mimics and their colorimetric biosensing |
https://doi.org/10.1016/j.bios.2020.112342 |
Metal oxide |
Magnetic hierarchical flower-like Co3O4 spheres |
| 3489 |
283 |
Ir nanoparticles with multi-enzyme activities and its application in the selective oxidation of aromatic alcohols |
https://doi.org/10.1016/j.apcatb.2020.118725 |
Metal |
citrate capped iridium nanoparticles (Cit-IrNPs) |
| 3518 |
321 |
Graphdiyne-templated palladium-nanoparticle assembly as a robust oxygen generator to attenuate tumor hypoxia |
https://doi.org/10.1016/j.nantod.2020.100907 |
Composite |
Here, we described a strategy to prepare a stable nanocatalyst that two-dimensional (2D) graphdiyne (GDY) serves as a template to immobilize catalytic palladium nanoparticles (PdNPs) on the GDY surface. In the presence of H2O2, the PdNPs/GDY composite functions as an oxygen generator to decompose H2O2 to produce molecular oxygen, which efficiently attenuates tumor hypoxia and delays tumor growth |
| 3521 |
324 |
Facile Preparation of Homogeneous Copper Nanoclusters Exhibiting Excellent Tetraenzyme Mimetic Activities for Colorimetric Glutathione Sensing and Fluorimetric Ascorbic Acid Sensing |
https://doi.org/10.1021/acsami.0c11983 |
Metal |
Herein, a facile and green method for preparing monodisperse, homogeneous copper nanoclusters (Cu NCs) with smaller size was developed, which used cysteine as the template and hydrazine hydrate as a reductant to reduce Cu2+. |
| 3612 |
424 |
Nanozyme and aptamer-based immunosorbent assay for aflatoxin B1 |
https://doi.org/10.1016/j.jhazmat.2020.123154 |
Composite |
mesoporous SiO2/Au-Pt (m-SAP)/cDNA |
| 3670 |
483 |
A mesoporous encapsulated nanozyme for decontaminating two kinds of wastewater and avoiding secondary pollution |
https://doi.org/10.1039/D0NR03217D |
Composite |
deposition of AuPtCo tri-metal in the pores of the dendrimer-like macroporous silica nanoparticles (DMSN)(DMSN@AuPtCo) |
| 3693 |
506 |
A nanozyme‐based artificial peroxisome ameliorates hyperuricemia and ischemic stroke |
https://doi.org/10.1002/adfm.202007130 |
Carbon |
FeN-carbon hollow nano-structure |
| 3742 |
555 |
Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy |
https://doi.org/10.1007/s12274-020-2844-3 |
Composite |
MnO2–Au |
| 3778 |
591 |
Toward supramolecular nanozymes for the photocatalytic activation of Pt (iv) anticancer prodrugs |
https://doi.org/10.1039/d0cc03450a |
Composite |
Au nanoparticles decorated with a C11-thiol bearing a 1,4,7-triazacyclononane headgroup (TACN AuNPs) |
| 3784 |
597 |
Point-of-care assay for drunken driving with Pd@ Pt core-shell nanoparticles-decorated ploy (vinyl alcohol) aerogel assisted by portable pressure meter |
https://doi.org/10.7150/thno.42601 |
Composite |
Pd@Pt core-shell nanoparticles (abbreviated to Pd@Pt). the proposed PAA/Pd@Pt composite (denoted as PAAC) can also work as glucose sensor by replacing the AOX to glucose oxidase (GOX) |
| 3792 |
605 |
Intrinsic catalase-mimicking MOFzyme for sensitive detection of hydrogen peroxide and ferric ions |
https://doi.org/10.1016/j.microc.2020.105873 |
MOF |
cerium MOFs (Ce-MOF) |
| 3793 |
606 |
Ultrasmall platinum nanozymes as broad-spectrum antioxidants for theranostic application in acute kidney injury |
https://doi.org/10.1016/j.cej.2020.127371 |
Composite |
ultrasmall polyvinylpyrrolidone-coated platinum nanoparticles (Pt NPs-PVP, ~3 nm) |
| 3800 |
614 |
Preparation of PbS NPs/RGO/NiO nanosheet arrays heterostructure: Function-switchable self-powered photoelectrochemical biosensor for H2O2 and glucose monitoring |
https://doi.org/10.1016/j.bios.2020.112803 |
Composite |
PbS nanoparticles (PbS NPs)/reduced graphene oxide (RGO)/NiO nanosheet arrays (NiO NSAs) heterostructure |
| 3801 |
615 |
A versatile Pt-Ce6 nanoplatform as catalase nanozyme and NIR-II photothermal agent for enhanced PDT/PTT tumor therapy |
https://doi.org/10.1007/s40843-020-1431-5 |
Composite |
In this study, we used porous Pt nanoparticles as a catalase (CAT) nanozyme, the second near-infrared (NIR-II) region photo_x0002_thermal transition agents (PTAs), and carriers of photosensitizer chlorin e6 (Ce6) to synthesize a composite nanosystem Pt-Ce6. |
| 3805 |
619 |
Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors |
https://doi.org/10.1016/j.biomaterials.2020.120537 |
Composite |
integrating DOX with the Fe(VI)-nanoplatform, followed by incorporation of n-heneicosane (HE) and polyethylene glycol (PEG) chains (designated as DOX-Fe(VI)@HMS-HE-PEG, abbreviated as DFHHP) |
| 3813 |
627 |
Ferric Ion Driven Assembly of Catalase‐like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors |
https://doi.org/10.1002/anie.202010005 |
Others |
supramolecular photosensitizing assembly of aminoacids |
| 3824 |
638 |
Genetically engineered magnetic nanocages for cancer magneto-catalytic theranostics |
https://doi.org/10.1038/s41467-020-19061-9 |
Metal oxide |
Encapsulin-produced magnetic iron oxide nanocomposites |
| 3839 |
653 |
Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation |
https://doi.org/10.1016/j.isci.2020.101483 |
Metal oxide |
MnO2 as Catalase mimic |
| 3853 |
667 |
Nanoceria: Metabolic interactions and delivery through PLGA-encapsulation |
https://doi.org/10.1016/j.msec.2020.111003 |
Metal oxide |
The biocompatibility and tunable degradation of poly(lactic-co-glycolic acid) (PLGA) made it a candidate material for encapsulating both nanoceria and SOD. |
| 3984 |
798 |
Enhanced Multiple Enzymelike Activity of PtPdCu Trimetallic Nanostructures for Detection of Fe2+ and Evaluation of Antioxidant Capability |
https://doi.org/10.1021/acssuschemeng.0c08230 |
Multi-metal |
PtPdCu trimetallic nanoalloys (TNAs) (PtPdCu TNAs) |
| 4049 |
863 |
An Activatable Nanoenzyme Reactor for Coenhanced Chemodynamic and Starving Therapy Against Tumor Hypoxia and Antioxidant Defense System |
https://doi.org/10.31635/ccschem.020.202000259 |
Composite |
activatable nanoenzyme reactor(NER):Fluorescent reporters (FRs) and bioenzyme glucose oxidase (GOX) were coassembled on nanozyme manganese dioxide nanosheets(MDN), which was enwrapped by the tumor-targeting material, hyaluronic acid (HA). |
| 4051 |
865 |
Fabrication and Application of Magnetically Catalytic Imprinting Nanozymes |
https://doi.org/10.1002/slct.202000900 |
Composite |
molecularly imprinted polymers (MIPs) based on polypyrrole (PPy) and using methylene blue (MB) as template were grown on Fe3O4 nanozymes(Fe3O4@PPy MIPs) |
| 4053 |
867 |
Revealing Kinetics of Two-Electron Oxygen Reduction Reaction at Single-Molecule Level |
https://doi.org/10.1021/jacs.0c06020 |
Metal oxide |
The uniform 8.3 nm sized Fe3O4 NPs were prepared using the previously reported
method |
| 4054 |
868 |
An Ultrasmall RuO2 Nanozyme Exhibiting Multienzyme-like Activity for the Prevention of Acute Kidney Injury |
https://doi.org/10.1021/acsami.0c07886 |
Metal oxide |
the ultrasmall RuO2NPs promising as a nanozyme for the prevention of AKI |
| 4065 |
879 |
Manganese oxide functionalized silk fibers for enzyme mimic application |
https://doi.org/10.1016/j.reactfunctpolym.2020.104565 |
Metal oxide |
optimally prepared MnO2-Silk for
catalase, oxidase, and peroxidase-like activities |
| 4070 |
884 |
An ultrasensitive label-free colorimetric biosensor for the detection of glucose based on glucose oxidase-like activity of nanolayered manganese-calcium oxide |
https://doi.org/10.1016/j.aca.2020.03.021 |
Composite |
nanolayered manganese-calcium (MneCa) oxide (NL-MnCaO2) |
| 4081 |
895 |
BSA-decorated magnesium nanoparticles for scavenging hydrogen peroxide from human hepatic cells |
https://doi.org/10.1021/acsanm.0c00088 |
Metal |
bovine serum albumin (BSA) coated magnesium nanoparticles (BSA-MgNPs) with respect to the protection of mammalian hepatic cells with depleted cellular catalase enzyme |
| 4084 |
898 |
Citric acid-crosslinked β-cyclodextrin supported zinc peroxide as a biocompatible H 2 O 2 scavenger |
https://doi.org/10.1007/s00775-020-01771-6 |
Metal oxide |
H2O2 scavenger |
| 4090 |
904 |
Protoporphyrin‐IX and Manganese Oxide Nanoparticles Encapsulated in Niosomes as Theranostic |
https://doi.org/10.1002/slct.201901620 |
Composite |
Protoporphyrin-IX and Manganese Oxide Nanoparticles Encapsulated in Niosomes |
| 4096 |
910 |
Study on the dissolution of hollow mesoporous silica nanosphere-supported nanosized platinum oxide in biorelevant media for evaluating its potential as chemotherapeutics |
https://doi.org/10.1016/j.jcis.2019.09.114 |
Composite |
hollow mesoporous silica nanosphere-supported nanosized platinum oxide |
| 4103 |
917 |
Carbon nanocage-based nanozyme as an endogenous H 2 O 2-activated oxygenerator for real-time bimodal imaging and enhanced phototherapy of esophageal cancer |
https://doi.org/10.1039/D0NR05945E |
Composite |
|
| 4128 |
942 |
In situ formation and immobilization of gold nanoparticles on polydimethylsiloxane (PDMS) exhibiting catalase-mimetic activity |
https://doi.org/10.1039/D0CC01344G |
Composite |
gold nanoparticles (AuNPs) immobilized on the surface of polydimethylsiloxane (PDMS) |
| 4137 |
951 |
2D LDH-MoS 2 clay nanosheets: synthesis, catalase-mimic capacity, and imaging-guided tumor photo-therapy |
https://doi.org/10.1186/s12951-020-00763-7 |
Composite |
Mg–Mn–Al layered double hydroxides (LDH) clay with MoS2 doping (LDH-MoS2) |
| 4138 |
952 |
Construction of heparin-based hydrogel incorporated with Cu5. 4O ultrasmall nanozymes for wound healing and inflammation inhibition |
https://doi.org/10.1016/j.bioactmat.2021.02.006 |
Composite |
heparin-based hydrogel incorporated with Cu5.4O (Cu5.4O@Hep-PEG) |
| 4140 |
954 |
Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis |
https://doi.org/10.1016/j.bioactmat.2021.01.016 |
Other |
hollow Prussian blue nanozymes (HPBzymes) |
| 4161 |
975 |
Multi-enzymatic activities of ultrasmall ruthenium oxide for anti-inflammation and neuroprotection |
https://doi.org/10.1016/j.cej.2021.128543 |
Metal oxide |
RuO2 |
| 4163 |
977 |
Multi-enzymatic activities of ultrasmall ruthenium oxide for anti-inflammation and neuroprotection |
https://doi.org/10.1016/j.cej.2021.128543 |
Metal oxide |
RuO2 |
| 4181 |
995 |
Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management |
https://doi.org/10.1016/j.biomaterials.2021.120706 |
Others |
In this study, we reported ultrasmall polyvinylpyrrolidone-coated iridium nanoparticles (denoted as Ir NPs-PVP, 1.5 nm) as multi-enzyme mimetic to scavenge a variety of RONS, offering an efficient RONS-induced cellular protection. |
| 4194 |
1007 |
Catalase-like nanosystem for interlocking trimodal cancer therapy with hypoxia relief |
https://doi.org/10.1007/s40843-020-1492-3 |
Composite |
Herein, a catalase-like nanovesicle with near-infrared light-responsiveness, that is, platinum/gold nanoshell encapsulated chlorin e6 (Ce6)/resveratrol (Res) liposome (Pt@Au-Ce6/Res-Lip), was developed to surmount this intractable issue. |
| 4205 |
1018 |
Hydrolytic cleavage of nerve agent simulants by gold nanozymes |
https://doi.org/10.1016/j.jhazmat.2021.125644 |
Composite |
gold nanoparticles passivated with thiolated molecules bearing 1,3,7-triazacyclononane and 1,3,7,10-tetraazacyclododecane ligands |
| 4211 |
1024 |
Atomic Engineering of Clusterzyme for Relieving Acute Neuroinflammation through Lattice Expansion |
https://doi.org/10.1021/acs.nanolett.0c05148 |
Composite |
Au24Ag1 clusterzyme |
| 4231 |
1044 |
Colorimetric determination of cysteine based on inhibition of GSH-Au/Pt NCs as peroxidase mimic |
https://doi.org/10.1016/j.saa.2020.119257 |
Composite |
Glutathionemodified gold-platinum nanoclusters (GSH-Au/Pt NCs) with different Au/Pt molar ratios were prepared via one-pot approach and utilized as peroxidase mimics to catalyze the oxidation of 3,3’,5,5’-tetramethyl benzidine (TMB) by H2O2. |
| 4234 |
1047 |
Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics |
https://doi.org/10.1038/s41467-021-21714-2 |
Metal oxide |
ceria nanoparticles (CNPs) |
| 4237 |
1050 |
Inhibition of Mitochondrial ATP Synthesis and Regulation of Oxidative Stress Based on {SbW8O30} Determined by Single‐Cell Proteomics Analysis |
https://doi.org/10.1002/anie.202100297 |
Others |
the novel {SbW8O30} compound synthesized by the one-step solution [{Na(H2O)3}2{Na4(H2O)12 Ni2(H2O)2(Sb2W2O5)}(SbW8O30)2] ⋅13 H2O(Na4Ni2Sb2W2-SbW8) |
| 4249 |
1062 |
Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengers |
https://doi.org/10.1002/adma.202006570 |
Composite |
Fenozymes |
| 4277 |
1090 |
Mechanism and Dynamics of Fast Redox Cycling in Cerium Oxide Nanoparticles at High Oxidant Concentration |
https://doi.org/10.1021/acs.jpcc.1c00382 |
Metal oxide |
Ceria nanocrystals (nanoceria) |
| 4340 |
1155 |
Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions |
https://doi.org/10.1038/s41467-020-20275-0 |
Multi-metal |
Au25, Au24Cu1 and Au24Cd1 |
| 4391 |
1206 |
In situ synthesis of copper–ruthenium bimetallic nanoparticles on laser-induced graphene as a peroxidase mimic |
https://doi.org/10.1039/D0CC07518C |
Composite |
in situ synthesis of copper–ruthenium bimetallic nanoparticles on a laser-induced graphene surface (Cu–Ru/LIG) |
| 4429 |
1245 |
In Vivo Regenerable Cerium Oxide Nanozyme-Loaded pH/H2O2-Responsive Nanovesicle for Tumor-Targeted Photothermal and Photodynamic Therapies |
https://doi.org/10.1021/acsami.0c19074 |
Metal oxide |
CeO2 |
| 4433 |
1249 |
Dietary Fe3O4 Nanozymes Prevent the Injury of Neurons and Blood–Brain Barrier Integrity from Cerebral Ischemic Stroke |
https://doi.org/10.1021/acsbiomaterials.0c01312 |
Metal oxide |
Fe3O4 |
| 4481 |
1311 |
Composition and morphology effects on catalase mimetic activity of potential bioactive glasses |
https://doi.org/10.1016/j.ceramint.2020.07.067 |
Metal oxide |
Metal oxide into the glass composition |
| 4482 |
1312 |
Hemoglobin-Based Oxygen Carriers Incorporating Nanozymes for the Depletion of Reactive Oxygen Species |
https://doi.org/10.1021/acsami.0c14822 |
Composite |
Poly(lactide-co-glycolide) core decorated with Hb and nanozymes |
| 4483 |
1313 |
Biodegradable Hollow Manganese Silicate Nanocomposites to Alleviate Tumor Hypoxia toward Enhanced Photodynamic Therapy |
https://doi.org/10.1021/acsabm.0c01079 |
Others |
a hollow manganese silicate (HMnOSi) nanoparticle and a photosensitizer (Ce6) |